Kinase inhibitor library
Bikins are novel and patented kinase inhibitor libraries which contains 500 small molecules.
They are based on a new chemotype (a natural fragment).
They are based on a new chemotype (a natural fragment) and focus mainly on allosteric Type III and IV.
New scaffold able to generate selective
Type I-IV kinase inhibitors
An upfront bioinformatic analysis allows us to focus the synthesis on high promising drugs (high scoring value).
We select around about 20 kinases based on structural diversity and calculate the binding of the proposed molecules.
Our goal is to offer a library where you should be able to pick Hits for your selected Kinase.
Focus on non-Type I to ensure long residence time= better clinical output.
High solubility (low cLogP) and low MW (<400)
High capability for branching